ANTI-DIABETIC EFFECTS OF GLUCOMANNO-OLIGOSACCHARIDES VIA AMPK ACTIVATION IN C2C12 MYOTUBES
نویسندگان
چکیده
Abstract-HCTN7. In this paper, antidiabetic activities of glucomanno-oligosaccharides (GMO) in vitro and vivo were investigated. GMO significantly increased AMP-activated protein kinase (AMPK) phosphorylation a concentration-independent manner. Treatment with 100μg/ml 50μg/ml for 1 hour caused 1.47-fold 1.81-fold AMPK, respectively. Oral administration (6g/kg-1 body weight day-1) lowered blood glucose levels (p < 0.05) at 120 min as compared to control group. These results suggested that exhibited anti-diabetic effects via activation AMPK could be useful diabetes prevention
منابع مشابه
Mild Heat Stress Induces Mitochondrial Biogenesis Associated with Activation of the AMPK- SIRT1-PGC-1α Pathway in C2C12 Myotubes
.............................................................................................1 DEDICATION............................................................................................i TABLE OF CONTENTS................................................................................ii LIST OF TABLES AND FIGURES..................................................................iii AC...
متن کاملTime course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR.
The role of the AMP-activated kinase (AMPK) as a metabolic sensor in skeletal muscle has been far better characterized for glucose and fat metabolism than for protein metabolism. Therefore, the studies presented here were designed to examine the effects of 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside (AICAR)-induced AMPK signaling on effector mechanisms of mRNA translation and protein...
متن کاملاثر ضددیابتی عصاره زردچوبه از مسیر سلولی غیروابسته به انسولین AMPK
Introduction: Blood glucose is high in diabetic patients. It is taken from blood by two separate pathways: Insulin-dependent pathway of phosphoinositide 3 kinase (PI3K) and insulin-independent pathway AMPK (AMP-Activated protein kinase). The first pathway is impaired in type 2 diabetic patients, but the second pathway is active. On the other hand, curcuma longa extract containing a high percent...
متن کاملMultiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes.
Mutations in the gene that encodes the principal l-carnitine transporter, OCTN2, can lead to a reduced intracellular l-carnitine pool and the disease Primary Carnitine Deficiency. l-Carnitine supplementation is used therapeutically to increase intracellular l-carnitine. As AMPK and insulin regulate fat metabolism and substrate uptake, we hypothesized that AMPK-activating compounds and insulin w...
متن کاملLeucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes
Previous studies from this laboratory demonstrate that dietary leucine protects against high fat diet-induced mitochondrial impairments and stimulates mitochondrial biogenesis and energy partitioning from adipocytes to muscle cells through SIRT1-mediated mechanisms. Moreover, β-hydroxy-β-methyl butyrate (HMB), a metabolite of leucine, has been reported to activate AMPK synergistically with resv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Vietnam Journal of Science and Technology
سال: 2021
ISSN: ['2525-2518']
DOI: https://doi.org/10.15625/2525-2518/59/4/15518